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MYP_018199
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Basic Information
S-6K-F17-3GN (Derived from S-6K-F17)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Standard
17 amino acids
C87H137N25O19
Standard
Sequence
KKKKKKNGFAAWGAFGA
Physicochemical Analysis
1837.17 Da
10.70
5.75
5.54
0.3385
-0.95
0.26
-0.16
-15.52
23.53
0.1765
5500.00
5500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
743.92
-6.01
26.0
25.0
65.0
131.0
4.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0104960 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The 'A' at position 10 and 14 are 2-(4'-pentenyl)alanine residues and there is a hydrocarbon staple crosslinking them
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
PMID29275987 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29275987/
RECORD: Rec_0160424 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The 'A' at position 10 and 14 are 2-(4'-pentenyl)alanine residues and there is a hydrocarbon staple crosslinking them
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
4.2 μM
MIC
PMID29275987 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29275987/
RECORD: Rec_0191928 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The 'A' at position 10 and 14 are 2-(4'-pentenyl)alanine residues and there is a hydrocarbon staple crosslinking them
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Hemolytic
human red blood cells
PMID29275987 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29275987/
RECORD: Rec_0278935 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
32630
Structure & Mods
cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The 'A' at position 10 and 14 are 2-(4'-pentenyl)alanine residues and there is a hydrocarbon staple crosslinking them
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative Hemolytic
PMID29275987 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29275987/
RECORD: Rec_0362570 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
hydrocarbon-stapled side-chain cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation
The Ⓧ (position: 10 and 14) in sequence indicates 2-(4'-pentenyl) alanine. Ⓧ (10) and Ⓧ (14) are cross-linked by hydrocarbon stapling
Bio-Activity Profile
Hemolytic
human red blood cells
587 μM
MHC
PaperTracy A Stone, Gregory B Cole, Huong Q Nguyen, Simon Sharpe, Charles M Deber. Influence of hydrocarbon-stapling on membrane interactions of synthetic antimicrobial peptides. Bioorg Med Chem. 2018 Mar 15;26(6):1189-1196. Epub 2017 Oct 21. PMID29275987 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29275987/
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