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MYP_018173
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Basic Information
Circulin E
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
30 amino acids
C148H228N38O43S6
Standard
Sequence
KIPCGESCVWIPCLTSVFNCKCENKVCYHD
Physicochemical Analysis
3420.01 Da
6.72
-0.21
-0.56
-0.0069
0.09
0.39
0.08
26.79
68.00
0.1000
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1291.17
-11.63
49.0
50.0
107.0
235.0
7.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0371980 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 10.0%, E 0.0%, T 56.7%, C 33.3% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0382406 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1
0.05-0.275 μM
EC50
PaperPubMed PMID: 10691702 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10691702;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
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