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MYP_018173
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Basic Information
Circulin E
Antimicrobial
Antiviral
Antiviral ▸ Anti-HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Standard
30 amino acids
C148H228N38O43S6
Standard
Sequence
KIPCGESCVWIPCLTSVFNCKCENKVCYHD
Physicochemical Analysis
3420.01 Da
6.72
-0.21
-0.56
-0.0069
0.09
0.39
0.08
26.79
68.00
0.1000
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1291.17
-11.63
49.0
50.0
107.0
235.0
7.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0039230 VERIFIED: YES
Provenance & Taxonomy
Chassalia kolly [Plant]
Structure & Mods
DNA-encoded linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0067943 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
cyclic peptide; DSSP H 0.0%, E 0.0%, T 53.3%, C 46.7% [Cyclic]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0113485 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
NOTE: EC50 = concentration that is 50% effective
PaperPubMed PMID: 10691702 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10691702;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
RECORD: Rec_0134864 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization
Cyclization
4-20; 8-22; 13-27
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 10691702 | Cyclotides as natural anti-HIV agents. Biopolymers. 2008;90(1):51-60. doi: 10.1002/bip.20886. PMID: 18008336. PMID10691702;18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/10691702/
RECORD: Rec_0149165 VERIFIED: YES
Provenance & Taxonomy
Chassalia parviflora [Plant]
Defensin
58431
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
Cyclization (N termini to C termini)
Cyclization (N termini to C termini)
4-20, 8-22, 13-27
Disulfide bonds between Cys4 and Cys20, Cys8 and Cys22,Cys13 and Cys27.
Bio-Activity Profile
Antiviral Anti-HIV Entry inhibition
HIV
0.05-0.275 μM
EC50
Mammalian: 1.3 h; Yeast: 3 min; E. coli: 2 min
PaperCyclotides as natural anti-HIV agents. | Ireland DC, Wang CK, Wilson JA, Gustafson KR, Craik DJ. | Biopolymers. 2008;90(1):51-60. | DOI:10.1002/bip.20886 | PMID:18008336 PMID18008336 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18008336/
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