Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length405 amino acids

Chemical FormulaC2009H3152N556O570S11

DescriptionStandard

        YRGSQSPGSSRAPLWIGIHCVRNSSFTRRLSGGGDAPSAPAAHQQGIAVLEQELAQLKLPDISGDFRIRHVGKVHYEISSLDLRSFHLPYSRISLVPSVGLQVSISNAFAEVDGNWRVKLRDHGSFDLKVENVYIKINLQLGSDASGKPTADTSDCSTRISKVRVHFSGKFGYLRCLPCPQVCQIVVKSVRSELQPYLRTLPVTARIDARAGIDYSLVAPPTATAQSLDVDLKGEFFSLAHRSAVPFAPLPLAFPPDHDRMVYFGASSYFFNTAGRAYHSAGALVFEITDSMIPKGVEFHLNTTTFSAFIPQLERMYPDMLMKLRLSAPSAPFLDIGPEGLSLRPVVDIQAYAILPNSSLAPLFLLTGWELLLPLGQPSQRRSSLRRMRLSLKHSDVGTFQVSYP
    

Molecular Weight44566.62 Da

Isoelectric Point (pI)9.33

Net Charge (pH 7.0)9.79

Net Charge (pH 7.4) 8.83

Charge Density (pH 7.0) 0.0242

GRAVY Index-0.05

Hydrophobic Moment 0.66

Boman Index0.06

Instability Index46.46

Aliphatic Index 92.47

Aromaticity 0.0914

Extinction Coeff. Reduced 35870.00

Extinction Coeff. Oxidized 36120.00

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Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0182134 VERIFIED: NO

Provenance & Taxonomy

OrganismAthene cunicularia (Burrowing owl) [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria