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MYP_018133
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-Influenza virus ▸ Anti-Influenza A ▸ Anti-Influenza A virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Standard
10 amino acids
C71H106N18O12
Standard
Sequence
FFVIFYRRKK
Physicochemical Analysis
1403.71 Da
11.10
3.76
3.55
0.3757
-0.10
0.26
-0.18
81.97
68.00
0.4000
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
521.29
-0.08
20.0
16.0
46.0
101.0
4.0
9.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0053523 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 40.0%, E 0.0%, T 0.0%, C 60.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0086143 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-Influenza A virus Fusion inhibition
Influenza A virus A/WSN/33 H1N1 | MDCK cells
1.482 μM
IC50
Mammalian: 1.1 h; Yeast: 3 min; E. coli: 2 min
PaperA novel family of peptides with potent activity against influenza A viruses. | Nicol MQ, Ligertwood Y, Bacon MN, Dutia BM, Nash AA. | J Gen Virol. 2012 May;93(Pt 5):980-986. | DOI:10.1099/vir.0.038679-0 | PMID:22258859 PMID22258859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22258859/
RECORD: Rec_0105017 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 22258859 PMID22258859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22258859/
RECORD: Rec_0107806 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
influenza A virus A/WSN/33 H1N1:inhibition of viral replication in MDCK cells
1.48175 μM
IC50
PaperPubMed PMID: 22258859 PMID22258859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22258859/
RECORD: Rec_0165524 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Influenza A virus (Virus entry); MDCK
1.48175 μM
Plaque assay
PaperA novel family of peptides with potent activity against influenza A viruses. | Nicol MQ, Ligertwood Y, Bacon MN, Dutia BM, Nash AA. | J Gen Virol. 2012 | PMID:22258859 PMID22258859 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22258859/