Peptide Database

Peptide NameDefensin alpha 4 (Defensin-related cryptdin-4)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length92 amino acids

Chemical FormulaC441H720N132O136S7

DescriptionStandard

        MKTLVLLSALVLLAFQVQADPIQNTDEETKTEEQPGEEDQAVSISFGGQEGSALHEKSLRGLLCYCRKGHCKRGERVRGTCGIRFLYCCPRR
    

Molecular Weight10271.69 Da

Isoelectric Point (pI)7.60

Net Charge (pH 7.0)0.64

Net Charge (pH 7.4) 0.20

Charge Density (pH 7.0) 0.0069

GRAVY Index-0.39

Hydrophobic Moment 0.68

Boman Index-0.10

Instability Index35.63

Aliphatic Index 80.54

Aromaticity 0.0543

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4359.70

LogP -47.08

H-bond Donors 158.0

H-bond Acceptors 146.0

Rotatable Bonds 351.0

Heavy Atoms 716.0

Ring Count 10.0

Amide Bonds 98.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0412916 VERIFIED: YES

Provenance & Taxonomy

OrganismMus musculus [Animal]

FamilyAlpha-defensin; Defensin

Tax ID10090

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibiotic Defensin Anti-Gram-negative Non-hemolytic

TargetEscherichia coli (Gram-negative)