Peptide Database

Peptide NameSLAY-screened peptide P5596

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC87H147N23O29S4

DescriptionStandard

        MQGCHSLEAMPTMTGSIISI
    

Molecular Weight2107.49 Da

Isoelectric Point (pI)5.22

Net Charge (pH 7.0)-1.42

Net Charge (pH 7.4) -1.70

Charge Density (pH 7.0) -0.0710

GRAVY Index0.55

Hydrophobic Moment 0.28

Boman Index0.32

Instability Index38.31

Aliphatic Index 83.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 817.65

LogP -9.39

H-bond Donors 29.0

H-bond Acceptors 33.0

Rotatable Bonds 69.0

Heavy Atoms 143.0

Ring Count 2.0

Amide Bonds 20.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0308360 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/