Peptide Database

Peptide NameSub3-D

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Standard StatusStandard

Sequence Length14 amino acids

Chemical FormulaC83H145N35O15

DescriptionStandard

        ARRWRIVVIRVRRH
    

Molecular Weight1873.26 Da

Isoelectric Point (pI)12.00

Net Charge (pH 7.0)5.88

Net Charge (pH 7.4) 5.64

Charge Density (pH 7.0) 0.4202

GRAVY Index-0.55

Hydrophobic Moment 0.54

Boman Index-0.58

Instability Index139.72

Aliphatic Index 125.00

Aromaticity 0.0714

Extinction Coeff. Reduced 5500.00

Extinction Coeff. Oxidized 5500.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 857.49

LogP -5.95

H-bond Donors 35.0

H-bond Acceptors 22.0

Rotatable Bonds 62.0

Heavy Atoms 133.0

Ring Count 3.0

Amide Bonds 13.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0173759 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermNone

C-TermAmidation

Other ModsD-residue notation at positions 1, 14; Mixed L/D stereochemistry with D-annotated positions 1, 14

Bio-Activity Profile

Function

Antimicrobial Anti-Gram-positive

TargetStaphylococcus aureus

Activity1 μg/mL

MethodMIC

Half-Life25% aqueous mouse serum, in vitro; ~3600 s

RECORD: Rec_0291517 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySub3

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

C-TermAmidation

Other ModsD-Ala at 1st position, D-His at 14th position

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetStaphylococcus aureus

Activity1 μg/mL

MethodMIC

Half-LifeMouse serum: With a half-life of approximately 1 h

PaperKnappe D, Henklein P, Hoffmann R, Hilpert K. Easy strategy to protect antimicrobial peptides from fast degradation in serum. Antimicrob Agents Chemother. 2010 Sep;54(9):4003-5. PMID:20585128 https://pubmed.ncbi.nlm.nih.gov/20585128/ PMID20585128 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20585128/

RECORD: Rec_0292766 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

N-TermNone

C-TermAmidation

Other ModsD-residue notation at positions 1, 14; Mixed L/D stereochemistry with D-annotated positions 1, 14

Bio-Activity Profile

Function

Antimicrobial

TargetPseudomonas aeruginosa

Activity2 μg/mL

MethodMIC

Half-Life25% aqueous mouse serum, in vitro; ~3600 s

RECORD: Rec_0309910 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilySub3

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

C-TermAmidation

Other ModsD-Ala at 1st position, D-His at 14th position

Bio-Activity Profile

Function

Antimicrobial Antibacterial

TargetPseudomonas aeruginosa

Activity2 μg/mL

MethodMIC

Half-LifeMouse serum: With a half-life of approximately 1 h

PaperKnappe D, Henklein P, Hoffmann R, Hilpert K. Easy strategy to protect antimicrobial peptides from fast degradation in serum. Antimicrob Agents Chemother. 2010 Sep;54(9):4003-5. PMID:20585128 https://pubmed.ncbi.nlm.nih.gov/20585128/ PMID20585128 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20585128/