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MYP_017915
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Basic Information
Gallinacin-1 alpha (Gal-1 alpha; Antimicrobial peptide CHP2; Birds, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Standard
39 amino acids
C205H322N60O48S6
Standard
Sequence
GRKSDCFRKNGFCAFLKCPYLTLISGKCSRFHLCCKRIW
Physicochemical Analysis
4587.51 Da
9.70
7.78
7.43
0.1996
-0.09
0.54
-0.09
19.77
62.56
0.1538
6990.00
7365.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1764.04
-14.89
71.0
63.0
152.0
319.0
9.0
39.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0022852 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
9031
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Disulfide bond(s) reported
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
Candida albicans
PaperPubMed PMID: 7964174 | PubMed PMID: 8150085 PMID7964174;8150085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/7964174/
RECORD: Rec_0027973 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 10.3%, E 28.2%, T 33.3%, C 28.2% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0061433 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
Defensin
9031
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal
Escherichia coli ML-35, Listeria monocytogenes strain EGD
PaperGallinacins: cysteine-rich antimicrobial peptides of chicken leukocytes.
RECORD: Rec_0107074 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
-
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0137647 VERIFIED: YES
Provenance & Taxonomy
Gallus gallus [Animal]
Defensin
9031
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
6-28; 13-34; 18-35
Bio-Activity Profile
Antimicrobial
PMID8150085 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/8150085/
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