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MYP_017892
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Basic Information
Vasoactive intestinal peptide
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Antiprotozoal ▸ Anti-Trypanosoma
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Cardiovascular
Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide
Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity
Delivery / Targeting ▸ Barrier transport ▸ Blood-brain barrier shuttle ▸ Blood-Brain Barrier
Delivery / Targeting ▸ Drug delivery vehicle
Hormonal / Endocrine ▸ Hormone peptide
Immunology ▸ Immune modulation ▸ Immunomodulatory activity
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory
Immunology ▸ Inflammation modulation ▸ Anti-inflammatory ▸ attenuation of acute inflammation
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Metabolic
Neurological / Signaling ▸ Neuromodulation
Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide
Regulatory peptide ▸ Biological modulation
Regulatory peptide ▸ Biological regulation
Regulatory peptide ▸ Cell-cell communication
Standard
28 amino acids
C147H237N43O43S
Standard
Sequence
HSDAVFTDNYTRLRKQMAVKKYLNSILN
Physicochemical Analysis
3326.78 Da
9.82
2.84
2.58
0.1016
-0.64
0.60
-0.18
32.19
83.57
0.1071
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1447.90
-14.62
51.0
48.0
113.0
234.0
4.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0403857 VERIFIED: YES
Provenance & Taxonomy
Macaca mulatta [Animal]
Glucagon
9544
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Metabolic
PMID2003150 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/2003150/
RECORD: Rec_0405091 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
VIP
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Electrolyte and water secretion
Radioimmunoassay
New Zealand White rabbits plasma(have normal sodium diet i.e. 29.35 k 4.02 pmol/l), in vivo; 76.2 s
PMID1649728 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1649728/
RECORD: Rec_0412862 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Hormone-derived peptide
9606
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antitrypanosomal
Trypanosoma brucei brucei AnTat 1.1 (blood stage form)
2.8±0.6 μM
LD50; MTT assay
PaperNeuropeptides kill African trypanosomes by targeting intracellular compartments and inducing autophagic-like cell death PMID19057622 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19057622/
RECORD: Rec_0423693 VERIFIED: YES
Provenance & Taxonomy
Capra hircus [Animal]
Vasoactive intestinal peptide
9925
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Hormone Endocrine Neuropeptide Neuromodulator Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation
Experimental: ~1 minute; /60 seconds; Mammalian: 3.5 hour; Yeast: 10 min; E. coli: >10 hour
PaperSource-linked PubMed record(s) for Vasoactive intestinal peptide (Capra hircus): PMID 3748846##730072 PMID3748846;730072 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/3748846/
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