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MYP_017768
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Basic Information
Unnamed
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antibiotic activity
Immunology ▸ Innate immune defense ▸ Host defense peptide ▸ Host defense activity
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
113 amino acids
C476H740N132O166S4
Standard
Sequence
AAPTATVTPSSGLSDGTVVKVAGAGLQAGTAYDVGQCAWVDTGVLACNPADFSSVTADANGSASTSLTVRRSFEGFLFDGTRWGTVDCTTAACQVGLSDAAGNGPEGVAISFN
Physicochemical Analysis
11096.01 Da
4.05
-6.23
-6.49
-0.0551
0.21
0.49
0.20
28.72
70.89
0.0708
12490.00
12740.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
4711.04
-68.32
168.0
164.0
346.0
778.0
14.0
119.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0078900 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
RECORD: Rec_0096561 VERIFIED: NO
Provenance & Taxonomy
Streptomyces malayensis [Bacterium]
Neocarzinostatin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antibiotic Antimicrobial Anti-Gram-positive Cytotoxic Non-hemolytic Non-ribosomal
Gram-positive bacteria
Qualitative functional evidence
PMID1831044 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/1831044/; https://www.uniprot.org/uniprotkb/P0A3S0/entry; https://bblserver.org.in/ampdb/
RECORD: Rec_0276301 VERIFIED: YES
Provenance & Taxonomy
Streptomyces carzinostaticus [Bacterium]
neocarzinostatin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
37-47; 88-93
Bio-Activity Profile
Antimicrobial neocarzinostatin family Antibacterial Host defense
PaperPDB 2CBO structural record; X-ray; 1.70 A; chain A; residues 1-113
RECORD: Rec_0419995 VERIFIED: YES
Provenance & Taxonomy
Streptomyces malayensis [Bacterium]
neocarzinostatin family
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
37-47; 88-93
Bio-Activity Profile
Antimicrobial neocarzinostatin family Antibacterial Host defense
PaperPDB 4JW3 structural record; X-ray; 2.60 A; chain A/B; residues 1-112