Peptide Database

Peptide NameCaerin-1.19 (Frogs, amphibians, animals)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antiviral

Antiviral ▸ Anti-HIV

Antiviral ▸ Antiviral mechanism ▸ Viral release inhibition

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length25 amino acids

Chemical FormulaC127H212N32O29

DescriptionStandard

        GLFKVLGSVAKHLLPHVAPIIAEKL
    

Molecular Weight2651.24 Da

Isoelectric Point (pI)9.70

Net Charge (pH 7.0)1.93

Net Charge (pH 7.4) 1.62

Charge Density (pH 7.0) 0.0774

GRAVY Index0.90

Hydrophobic Moment 0.59

Boman Index0.37

Instability Index12.20

Aliphatic Index 156.00

Aromaticity 0.0400

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 937.09

LogP -2.92

H-bond Donors 31.0

H-bond Acceptors 33.0

Rotatable Bonds 86.0

Heavy Atoms 188.0

Ring Count 5.0

Amide Bonds 24.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0004982 VERIFIED: YES

Provenance & Taxonomy

OrganismLitoria gracilenta [Animal]

FamilyCaerin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral

TargetStaphylococcus aureus Strain ATCC 29213

Activity12 μg/mL

MethodMIC

RECORD: Rec_0007752 VERIFIED: YES

Provenance & Taxonomy

OrganismLitoria gracilenta [Animal]

FamilyCaerin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral

TargetVirus:HIV: inhibition of HIV Pseudovirus (PsV) infection in CD4+ T cells

Activity2.5 μM

MethodIC50

RECORD: Rec_0021255 VERIFIED: YES

Provenance & Taxonomy

OrganismLitoria gracilenta [Animal]

FamilyCaerin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antiviral

TargetMicrococcus luteus

Activity25 μg/mL

MethodMIC

RECORD: Rec_0021809 VERIFIED: YES

Provenance & Taxonomy

OrganismLitoria gracilenta [Animal]

FamilyCaerin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative

TargetListeria innocua

Activity12 μg/mL

MethodMIC

RECORD: Rec_0031181 VERIFIED: YES

Provenance & Taxonomy

OrganismLitoria gracilenta [Animal]

FamilyCaerin

Structure & Mods

Configribosomal mature linear peptide [Linear]

ChiralityGene-encoded natural peptide composed of standard L-amino acids [L]

C-TermAmidation

Bio-Activity Profile

Function

Antimicrobial Antibacterial

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