Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length69 amino acids

Chemical FormulaC314H520N84O106S4

DescriptionStandard

        MQEKRQQLVQVVSDTELEVLIGGKGPGLVKTLTKDYPEVLSEVCGGIAASVEYVVGAQIDASGCKNCEN
    

Molecular Weight7296.25 Da

Isoelectric Point (pI)4.53

Net Charge (pH 7.0)-4.51

Net Charge (pH 7.4) -4.80

Charge Density (pH 7.0) -0.0654

GRAVY Index-0.04

Hydrophobic Moment 0.54

Boman Index0.08

Instability Index25.07

Aliphatic Index 98.70

Aromaticity 0.0290

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3105.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3073.24

LogP -33.50

H-bond Donors 105.0

H-bond Acceptors 106.0

Rotatable Bonds 250.0

Heavy Atoms 508.0

Ring Count 4.0

Amide Bonds 75.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0323412 VERIFIED: NO

Provenance & Taxonomy

OrganismDolosigranulum pigrum [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence