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MYP_017646
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Basic Information
Unnamed
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Flavivirus ▸ Anti-West Nile virus
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
13 amino acids
C59H100N16O18S2
Standard
Sequence
CDVIALLACHLNT
Physicochemical Analysis
1385.65 Da
5.08
-1.17
-1.45
-0.0901
1.37
0.32
0.41
76.39
157.69
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
541.82
-4.35
20.0
20.0
43.0
95.0
1.0
13.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0072928 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0115065 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral
Inhibition of virus attachment to Vero cells
1000 μM
% inhibition
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperAntiviral peptides targeting the west nile virus envelope protein. | Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E. | J Virol. 2007 Feb;81(4):2047-55. | DOI:10.1128/JVI.01840-06 | PMID:17151121 PMID17151121 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17151121/
RECORD: Rec_0174237 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
west nile virus(WNV):inhibition of virus infection in Vero cells
2.60±0.01 μM
IC50
PaperPubMed PMID: 17151121 PMID17151121 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17151121/
RECORD: Rec_0186595 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-WNV Infection inhibition
West nile virus(WNV) | Vero cells
2.6±0.01 μM
IC50
Mammalian: 1.2 h; Yeast: >20 h; E. coli: >10 h
PaperAntiviral peptides targeting the west nile virus envelope protein. | Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E. | J Virol. 2007 Feb;81(4):2047-55. | DOI:10.1128/JVI.01840-06 | PMID:17151121 PMID17151121 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17151121/
RECORD: Rec_0231971 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Library-derived peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
West Nile virus (Virus entry); Vero
96.3 %
qPCR
PaperAntiviral peptides targeting the west nile virus envelope protein. | Bai F, Town T, Pradhan D, Cox J, Ashish, Ledizet M, Anderson JF, Flavell RA, Krueger JK, Koski RA, Fikrig E. | J Virol. 2007 | PMID:17151121 PMID17151121 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/17151121/
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