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MYP_017635
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Basic Information
Tigerinin-4 (Frogs, amphibians, animals)
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic
Standard
11 amino acids
C57H94N14O13S2
Standard
Sequence
RVCYAIPLPIC
Physicochemical Analysis
1247.57 Da
8.06
0.74
0.51
0.0672
1.35
0.37
0.37
45.51
141.82
0.0909
1490.00
1615.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
418.87
-0.86
16.0
16.0
34.0
86.0
3.0
10.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0313779 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus tigerinus [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antifungal Anti-Yeast Anti-Gram-negative Anti-Gram-positive Non-hemolytic
Staphylococcus aureus
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
RECORD: Rec_0315314 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 45.5%, C 54.5% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antimicrobial Antifungal Anti-Gram-positive Anti-Gram-negative
PaperYADAMP: yet another database of antimicrobial peptides PMID22325123 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22325123/
RECORD: Rec_0402108 VERIFIED: YES
Provenance & Taxonomy
Rana tigerina [Animal]
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
Amidation; Cyclization
3-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Anti-Gram-negative Antifungal
rat erythrocytes
PMID11031261 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/11031261/
RECORD: Rec_0410413 VERIFIED: YES
Provenance & Taxonomy
Hoplobatrachus tigerinus [Animal]
Tigerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
Amidation
3-11
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
48.0 μM
MIC
PaperK.P. Sai et al. / The Journal of Biological Chemistry 276 (2001) 2701-2707. Tigerinins: Novel Antimicrobial Peptides from the Indian Frog Rana tigerina Evidence URLhttps://www.uniprot.org/uniprotkb/P82654/entry
RECORD: Rec_0416296 VERIFIED: NO
Provenance & Taxonomy
Rana tigerina [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial
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