Peptide Database

Peptide NameSLAY-screened peptide P4209

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC122H166N24O29S2

DescriptionStandard

        FPLMGFKYYYPCYTRSPSLY
    

Molecular Weight2496.90 Da

Isoelectric Point (pI)8.99

Net Charge (pH 7.0)1.74

Net Charge (pH 7.4) 1.52

Charge Density (pH 7.0) 0.0872

GRAVY Index-0.24

Hydrophobic Moment 0.42

Boman Index0.16

Instability Index75.68

Aliphatic Index 39.00

Aromaticity 0.3500

Extinction Coeff. Reduced 7450.00

Extinction Coeff. Oxidized 7450.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 839.61

LogP -2.48

H-bond Donors 31.0

H-bond Acceptors 33.0

Rotatable Bonds 69.0

Heavy Atoms 177.0

Ring Count 10.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0082194 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/