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MYP_017552
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Basic Information
Mouse beta-defensin-14
Antimicrobial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Standard
32 amino acids
C154H261N47O44S4
Standard
Sequence
LRKYYCKIRSGRCALIGCLPKEEEIGRCSLSG
Physicochemical Analysis
3603.27 Da
9.17
3.72
3.45
0.1164
-0.25
0.57
-0.15
69.07
88.44
0.0625
2980.00
3230.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1495.34
-14.57
59.0
52.0
124.0
249.0
3.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0062490 VERIFIED: NO
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Anti-Gram-negative
Escherichia coli TOP10
Mex pooled growth assay (OD_ID at 4.5 h; Wald adjusted p-value)
PaperKoch P, Schmitt S, Cardner M, Beerenwinkel N, Panke S, Held M. Discovery of antimicrobials by massively parallelized growth assays (Mex). Scientific Reports. 2022;12:4097. doi:10.1038/s41598-022-07755-7 PMID35260685 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35260685/
RECORD: Rec_0432240 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3 disulfide bonds reported, sites unresolved
Bio-Activity Profile
Antibacterial Antimicrobial
Staphylococcus aureus ATCC 12600
1.2 μM
MBC (microdilution; ≥99.9% killing)
PaperMouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3 PMID18332171
RECORD: Rec_0432241 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3 disulfide bonds reported, sites unresolved
Bio-Activity Profile
Antibacterial Antimicrobial
Staphylococcus aureus ATCC 12600
0.08–0.15 μM
LD90 (microdilution; 90% killing)
PaperMouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3 PMID18332171
RECORD: Rec_0432242 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3 disulfide bonds reported, sites unresolved
Bio-Activity Profile
Antibacterial Antimicrobial
Staphylococcus aureus ATCC 33593 (MRSA)
2.4 μM
MBC (microdilution; ≥99.9% killing)
PaperMouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3 PMID18332171
RECORD: Rec_0432243 VERIFIED: YES
Provenance & Taxonomy
Mus musculus [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
3 disulfide bonds reported, sites unresolved
Bio-Activity Profile
Antibacterial Antimicrobial
Staphylococcus aureus ATCC 33593 (MRSA)
0.30 μM
LD90 (microdilution; 90% killing)
PaperMouse Beta-Defensin-14, an Antimicrobial Ortholog of Human Beta-Defensin-3 PMID18332171
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