Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length473 amino acids

Chemical FormulaC2348H3787N605O654S19

DescriptionStandard

        MFPWRWLALLALIPLSLSANAGVKVKLTQKGLDFGRELFVASLQEKLMTIKVPDISGTERVDPIGKVHYSLTEMRIVKLGLPSSAIGLVPGTGFTMTITNAFLSLHGKWRVKYLRFIKDRGSFDLAIKSLSITTSISLRSDNMGLPAVAMASCTTTLGGVSVKLHGGASWLYNLFRRFIEKGLQSQLQKKLCPLVAESVSSMNQFLKTVNVMAPVDRYAEIAYPMVSSPDISSSSIGLNLKGEFYNIGNHMEPPFSPAPFFLPNQEQSMLYIGLSAFTANSASFVYNKAGTLSLKITDDMVPRSSPIRLTTNTFGVLIPQIAKLFPGLMMVLQLKMTKDPLSSIEANKVTVDAKSSLTAYAILANTKLAPLFVLNLDFSVSARVNVVGNKLAGAVTLNRLDMSLGKSYVGDFKVGSLSNIFQIVLKWVVLPTVNVRLKEGFPLPSLGKINLKNTQLQILKGYIMIGTDLQNSG
    

Molecular Weight51565.08 Da

Isoelectric Point (pI)9.85

Net Charge (pH 7.0)20.84

Net Charge (pH 7.4) 20.29

Charge Density (pH 7.0) 0.0441

GRAVY Index0.25

Hydrophobic Moment 0.81

Boman Index0.16

Instability Index38.95

Aliphatic Index 106.74

Aromaticity 0.0825

Extinction Coeff. Reduced 43890.00

Extinction Coeff. Oxidized 44015.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0078166 VERIFIED: NO

Provenance & Taxonomy

OrganismGadus morhua [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence