Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length475 amino acids

Chemical FormulaC2424H3788N648O688S14

DescriptionStandard

        MMARLYRVVVTLLLLAEVSGFEEGATNPGFVARITRKGLEYARRFGVAILKKELSTIKLPDFSGSFKVGWIKSVSYDFYRLTIHCFELRNSDLRLRPRQGVRASLSNNYMFVSGNWKVKKAFVTLDGTFDVNVDGISISVSLKLGKDQSGRPTASVAHCRNSIGHISVDISGQLSWILNLFHERIENNFKNILEQKICEMVRKSTTSHLEPYLRTLPVISMIDQVAGIDYSLVDAPEVTSQVLDTPFKGEFFGQNWHSPAPFDAPPKKHDHMVYFAVSEYVFNTASWVYHQAGHMNFTIQNHHIPLDSPIHLHTSSFRAIIPQLARLYPNMELELETSPESAPFLMFTPGSVTLMPVIDIQAFAVLPTSSDRKPLFQLRVTTNISATISVNSDRIAGSVTTGSKLKLELKHSNIRFINVELMEAILNYYALHTLYASLNAKLEEGFPLPLPRDTHLNSLELQVHENFLLLGANLD
    

Molecular Weight53464.84 Da

Isoelectric Point (pI)7.81

Net Charge (pH 7.0)2.10

Net Charge (pH 7.4) 0.82

Charge Density (pH 7.0) 0.0044

GRAVY Index-0.04

Hydrophobic Moment 0.84

Boman Index0.09

Instability Index32.60

Aliphatic Index 97.26

Aromaticity 0.0968

Extinction Coeff. Reduced 48360.00

Extinction Coeff. Oxidized 48485.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0255924 VERIFIED: NO

Provenance & Taxonomy

OrganismOdobenus rosmarus divergens [Animal]

FamilyBPI

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence