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MYP_017344
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Basic Information
RANATUERIN-2ONa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C128H227N37O40S4
Standard
Sequence
GLMDTVKNAAKNLAGQMLDKLKCKITGSC
Physicochemical Analysis
3052.66 Da
9.24
2.74
2.50
0.0944
-0.08
0.62
-0.00
0.08
87.59
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1272.78
-14.46
45.0
47.0
110.0
209.0
0.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0227827 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 72.4%, E 0.0%, T 13.8%, C 13.8% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Toxic Antimicrobial Hemolytic
PaperDADP: the database of anuran defense peptides PMID22467909 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/22467909/
RECORD: Rec_0228533 VERIFIED: YES
Provenance & Taxonomy
Lithobates onca [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-29
Bio-Activity Profile
Hemolytic Cytolytic
Erythrocytes
90.0 μM
HC50
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 151 (2010) 313-317. Primary structures of skin antimicrobial peptides indicate a close, but not conspecific, phylogenetic relationship between the leopard frogs Lithobates onca and Lithobates yavapaiensis (Ranidae)
RECORD: Rec_0284183 VERIFIED: YES
Provenance & Taxonomy
Lithobates onca [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-negative
Escherichia coli
50.0 μM
MIC
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 151 (2010) 313-317. Primary structures of skin antimicrobial peptides indicate a close, but not conspecific, phylogenetic relationship between the leopard frogs Lithobates onca and Lithobates yavapaiensis (Ranidae)
RECORD: Rec_0290879 VERIFIED: YES
Provenance & Taxonomy
Lithobates onca [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-29
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive
Staphylococcus aureus
200.0 μM
MIC
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 151 (2010) 313-317. Primary structures of skin antimicrobial peptides indicate a close, but not conspecific, phylogenetic relationship between the leopard frogs Lithobates onca and Lithobates yavapaiensis (Ranidae)
RECORD: Rec_0300332 VERIFIED: YES
Provenance & Taxonomy
Lithobates onca [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Candida albicans ATCC 90028
100 μM
MIC
PMID20044030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20044030/
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