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MYP_017344
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Basic Information
RANATUERIN-2ONa
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytolysis / cell lysis ▸ Cytolytic activity
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
29 amino acids
C128H227N37O40S4
Standard
Sequence
GLMDTVKNAAKNLAGQMLDKLKCKITGSC
Physicochemical Analysis
3052.66 Da
9.24
2.74
2.50
0.0944
-0.08
0.62
-0.00
0.08
87.59
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1272.78
-14.46
45.0
47.0
110.0
209.0
0.0
31.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0113486 VERIFIED: YES
Provenance & Taxonomy
Rana onca [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
23-29
Bio-Activity Profile
Antimicrobial Antifungal
Candida albicans
100 μM
MIC
PaperPrimary structures of skin antimicrobial peptides indicate a close, but not conspecific, phylogenetic relationship between the leopard frogs Lithobates onca and Lithobates yavapaiensis (Ranidae)
RECORD: Rec_0127510 VERIFIED: YES
Provenance & Taxonomy
Lithobates onca [Animal]
Ranatuerin
Structure & Mods
Linear peptide with a single intramolecular disulfide-stabilized loop [Linear]
Gene-encoded natural peptide composed of standard L-amino acids [L]
23-29
Bio-Activity Profile
Antimicrobial Antifungal
PaperJ.M. Conlon et al. / Comparative Biochemistry and Physiology, Part C 151 (2010) 313-317. Primary structures of skin antimicrobial peptides indicate a close, but not conspecific, phylogenetic relationship between the leopard frogs Lithobates onca and Lithobates yavapaiensis (Ranidae)
RECORD: Rec_0166666 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial
Human erythrocytes
90 μM
LD50
Paperhttps://pubmed.ncbi.nlm.nih.gov/20044030/ PMID20044030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20044030/
RECORD: Rec_0175163 VERIFIED: YES
Provenance & Taxonomy
Lithobates onca [Animal]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Amidation
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Hemolytic
erythrocytes
90 μM
LC50
RECORD: Rec_0190052 VERIFIED: YES
Provenance & Taxonomy
Lithobates onca [Animal]
Ranatuerin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal
Escherichia coli ATCC 25922
50 μM
MIC
PMID20044030 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/20044030/
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