Peptide Database

Peptide NameInsulin A chain

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC98H153N25O34S5

DescriptionStandard

        GIVEECCKGVCSMYQLENYCN
    

Molecular Weight2385.74 Da

Isoelectric Point (pI)4.25

Net Charge (pH 7.0)-2.27

Net Charge (pH 7.4) -2.54

Charge Density (pH 7.0) -0.1083

GRAVY Index-0.02

Hydrophobic Moment 0.49

Boman Index0.07

Instability Index45.12

Aliphatic Index 64.76

Aromaticity 0.0952

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3230.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 973.20

LogP -10.14

H-bond Donors 36.0

H-bond Acceptors 37.0

Rotatable Bonds 79.0

Heavy Atoms 162.0

Ring Count 2.0

Amide Bonds 23.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0083133 VERIFIED: YES

Provenance & Taxonomy

OrganismOrnithorhynchus anatinus [Animal]

FamilyInsulin

Tax ID9258

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide6-11

Bio-Activity Profile

Function

Hormone Endocrine Metabolic regulation Physiological regulation

Half-LifeMammalian: 30 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0136519 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/

RECORD: Rec_0398481 VERIFIED: YES

Provenance & Taxonomy

OrganismOrnithorhynchus anatinus [Animal]

FamilyInsulin

Tax ID9258

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Metabolic