Peptide Database

Peptide NameNatriuretic peptide TcNP-a

Function Ontology

Cardiovascular

Cardiovascular ▸ Vascular tone modulation ▸ Vasoactive peptide

Cardiovascular ▸ Vascular tone modulation ▸ Vasodilatory activity

Hormonal / Endocrine ▸ Hormone peptide

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC136H223N39O47S3

DescriptionStandard

        SGSETAKIGDGCFGLPIDRIGSASGMGCGSVPKP
    

Molecular Weight3252.65 Da

Isoelectric Point (pI)5.84

Net Charge (pH 7.0)-0.56

Net Charge (pH 7.4) -0.80

Charge Density (pH 7.0) -0.0164

GRAVY Index-0.02

Hydrophobic Moment 0.47

Boman Index0.15

Instability Index19.77

Aliphatic Index 60.29

Aromaticity 0.0294

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1344.47

LogP -19.62

H-bond Donors 48.0

H-bond Acceptors 50.0

Rotatable Bonds 105.0

Heavy Atoms 225.0

Ring Count 4.0

Amide Bonds 33.0

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0322428 VERIFIED: YES

Provenance & Taxonomy

OrganismTropidechis carinatus [Animal]

FamilyNatriuretic peptide TcNP

Tax ID100989

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide12-28

Bio-Activity Profile

Function

Hormone Endocrine Vasoactive Vasodilator Cardiovascular Metabolic regulation Physiological regulation Receptor modulation

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour