Peptide Database

Peptide NameLantibiotic

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Standard StatusStandard

Sequence Length61 amino acids

Chemical FormulaC276H437N77O92S8

DescriptionStandard

        MPKYDDFDLNLKQNVSDPNQEPRVTSLFWCTPGTCNNTCKGGSTLKSNCCVGSILCSLGGC
    

Molecular Weight6562.40 Da

Isoelectric Point (pI)5.94

Net Charge (pH 7.0)-0.57

Net Charge (pH 7.4) -0.90

Charge Density (pH 7.0) -0.0093

GRAVY Index-0.33

Hydrophobic Moment 0.38

Boman Index-0.00

Instability Index30.52

Aliphatic Index 59.02

Aromaticity 0.0656

Extinction Coeff. Reduced 6990.00

Extinction Coeff. Oxidized 7365.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 2729.91

LogP -36.81

H-bond Donors 98.0

H-bond Acceptors 100.0

Rotatable Bonds 212.0

Heavy Atoms 453.0

Ring Count 9.0

Amide Bonds 68.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0178575 VERIFIED: NO

Provenance & Taxonomy

OrganismEnterococcus hirae [Bacterium]

FamilyLantibiotic

Structure & Mods

Configlinear lantibiotic precursor [Linear]

Chiralitypost-translationally modified ribosomal peptide [Modified]

Other ModsLantibiotic-family precursor annotation suggests post-translational lanthionine/methyllanthionine thioether crosslinks in the mature peptide

Bio-Activity Profile

Function

Antibiotic Antimicrobial Bacteriocin Lantibiotic Anti-Gram-positive Non-hemolytic

TargetGram-positive bacteria

MethodQualitative functional evidence

RECORD: Rec_0336504 VERIFIED: NO