Peptide Database

Peptide Nameneuregulin-1

Function Ontology

Neurological / Signaling ▸ Signaling peptide

Standard StatusStandard

Sequence Length222 amino acids

Chemical FormulaC1026H1679N295O342S13

DescriptionStandard

        SGKKPESAAGSQSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRKNKPQNIKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNEIITGMPASTEGAYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLVKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCQPGFTGARCTENVPMKVQNQEKAEELYQK
    

Molecular Weight24035.92 Da

Isoelectric Point (pI)9.13

Net Charge (pH 7.0)8.50

Net Charge (pH 7.4) 8.04

Charge Density (pH 7.0) 0.0383

GRAVY Index-0.67

Hydrophobic Moment 0.67

Boman Index-0.13

Instability Index47.39

Aliphatic Index 60.23

Aromaticity 0.0495

Extinction Coeff. Reduced 12950.00

Extinction Coeff. Oxidized 13450.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.

2D CHEMICAL STRUCTURE

Drag to move

Drag to move. Use the buttons to zoom.

RECORD: Rec_0279639 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyGtoPdb endogenous peptide ligand

Tax ID9606

Structure & Mods

Configdisulfide-constrained cyclic peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfidereported in GtoPdb PTM annotation

Other ModsPredicted N-linked glycosylation of asparagine residues at positions 101, 107 and 145; predicted disulphide bond formation between cysteine resdiues at positions 38 and 93. Disulphide bond formation between cysteine residues at positions 163 and 177, 171 and 191, and 193 and 202

Bio-Activity Profile

Function

Signaling peptide

Targeterb-b2 receptor tyrosine kinase 3 (Human); erb-b2 receptor tyrosine kinase 4 (Human)

Activity1.3 nM

MethodKd