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MYP_017014
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Basic Information
NS5A-derived peptide C5A [I6L,I10L,V13L]
Antimicrobial
Antiviral
Antiviral ▸ Anti-Hepatitis virus ▸ Anti-HCV
Antiviral ▸ Anti-HIV ▸ Anti-HIV-1
Antiviral ▸ Anti-HIV ▸ HIV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Enzyme modulation ▸ Enzyme inhibition ▸ Infection inhibition
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Venom / Toxin ▸ General toxin ▸ Toxic
Standard
18 amino acids
C110H157N25O29S
Standard
Sequence
SWLRDLWDWLCELLSDFK
Physicochemical Analysis
2325.64 Da
4.23
-2.54
-2.77
-0.1414
-0.13
0.69
0.08
34.47
108.33
0.2222
16500.00
16500.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
882.97
-2.12
33.0
28.0
73.0
165.0
7.0
17.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0198790 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Hemolytic
human erythrocytes
107.5 μM
Hemolysis
PMID21801309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21801309/
RECORD: Rec_0200005 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
HIV
PMID21801309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21801309/
RECORD: Rec_0209857 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630.0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HCV HIV
Human erythrocytes
107.5 μM
MHC
PaperLi GR, He LY, Liu XY, et al. Rational design of peptides with anti-HCV/HIV activities and enhanced specificity. Chem Biol Drug Des. 2011 Nov;78(5):835-843. doi:10.1111/j.1747-0285.2011.01201.x. PMID21801309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21801309/
RECORD: Rec_0234458 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiviral
HIV-1:inhibition of pseudotyped HIV infection in TZM-BL cells
0.59±0.03 μM
IC50
PaperRational design of peptides with anti-HCV/HIV activities and enhanced specificity. Chem Biol Drug Des. 2011 Nov;78(5):835-843. doi: 10.1111/j.1747-0285.2011.01201.x. PMID: 21801309. PMID21801309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21801309/
RECORD: Rec_0261074 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Anti-HIV-1 Infection inhibition
HIV-1 | TZM-BL cells
0.59±0.03 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperRational design of peptides with anti-HCV/HIV activities and enhanced specificity. | Li GR, He LY, Liu XY, Liu AP, Huang YB, Qiu C, Zhang XY, Xu JQ, Yang W, Chen YX. | Chem Biol Drug Des. 2011 Nov;78(5):835-43. | DOI:10.1111/j.1747-0285.2011.01201.x | PMID:21801309 PMID21801309 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/21801309/
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