Peptide Database

Peptide NameInsulin-like growth factor II Ala-25 Del

Function Ontology

Cardiovascular

Enzyme modulation ▸ Enzyme inhibition ▸ ACE inhibition ▸ ACE inhibitory

Hormonal / Endocrine ▸ Hormone peptide

Metabolic

Regulatory peptide ▸ Biological modulation

Regulatory peptide ▸ Biological regulation

Standard StatusStandard

Sequence Length66 amino acids

Chemical FormulaC318H500N92O100S6

DescriptionStandard

        YRPSETLCGGELVDTLQFVCGDRGFYFSRPASRVSRRSRGIVEECCFRSCDLALLETYCATPAKSE
    

Molecular Weight7404.32 Da

Isoelectric Point (pI)6.43

Net Charge (pH 7.0)-0.28

Net Charge (pH 7.4) -0.59

Charge Density (pH 7.0) -0.0042

GRAVY Index-0.25

Hydrophobic Moment 0.91

Boman Index-0.10

Instability Index79.46

Aliphatic Index 65.00

Aromaticity 0.1061

Extinction Coeff. Reduced 4470.00

Extinction Coeff. Oxidized 4845.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 3111.68

LogP -35.41

H-bond Donors 119.0

H-bond Acceptors 106.0

Rotatable Bonds 240.0

Heavy Atoms 516.0

Ring Count 10.0

Amide Bonds 66.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0061104 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyInsulin-like growth factor II Ala-25 Del

Tax ID9606

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide8-46; 20-59; 45-50

Bio-Activity Profile

Function

Hormone Endocrine Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Targetglucose metabolism in adipose tissue

Half-LifeMammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min

RECORD: Rec_0127297 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyInsulin-like growth factor II Ala-25 Del

Tax ID9606

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide8-46; 20-59; 45-50

Bio-Activity Profile

Function

Hormone Endocrine Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Targeta developmental stage and tissue

Half-LifeMammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min

RECORD: Rec_0259217 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyInsulin-like growth factor II Ala-25 Del

Tax ID9606

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide8-46; 20-59; 45-50

Bio-Activity Profile

Function

Hormone Endocrine Cardiovascular Metabolic regulation Physiological regulation Growth regulation Development regulation Receptor modulation ACE inhibitory

Half-LifeMammalian: 2.8 hour; Yeast: 10 min; E. coli: 2 min

RECORD: Rec_0376394 VERIFIED: YES

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

FamilyInsulin

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone Metabolic