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MYP_016910
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Basic Information
Peptide 1b
Binding / Molecular interaction ▸ Binding activity
Enzyme modulation ▸ Enzyme inhibition ▸ Coagulation factor VIIa peptide exosite inhibitor
Standard
18 amino acids
C96H141N27O28S2
Standard
Sequence
ALCDNPRIDRWYCQFVEG
Physicochemical Analysis
2185.44 Da
4.56
-1.22
-1.44
-0.0678
-0.48
0.73
-0.09
33.61
65.00
0.1667
6990.00
7115.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
907.13
-7.20
33.0
29.0
67.0
153.0
5.0
19.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0256712 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation [(C6H6)(CH2)4CH3]
Amidation
Bio-Activity Profile
Receptor-binding
fVIIa binding assay in presence of 0.1% rabbit serum albumin
0.022 μM
IC50
Intravenouly administered into rabbit blood, in vivo; 4746 s
PMID12699744 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12699744/
RECORD: Rec_0263132 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation [(C6H6)-(C6H12)-(C6H6)]
Amidation
Bio-Activity Profile
Receptor-binding
fVIIa binding assay in presence of 0.1% rabbit serum albumin
0.09 μM
IC50
Intravenouly administered into rabbit blood, in vivo; 13320 s
PMID12699744 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12699744/
RECORD: Rec_0272138 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Receptor-binding
fVIIa binding assay
0.0146 μM
IC50
Intravenouly administered into rabbit blood, in vivo; 1440 s
PMID12270169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12270169/
RECORD: Rec_0322786 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Receptor-binding
fVIIa binding assay
0.004 μM
IC50
Intravenouly administered into rabbit blood, in vivo; 900 s
PMID12270169 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12270169/
RECORD: Rec_0347659 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acylation (Naphthalene)
Amidation
Bio-Activity Profile
Receptor-binding
fVIIa binding assay in presence of 0.1% rabbit serum albumin
0.0092 μM
IC50
Intravenouly administered into rabbit blood, in vivo; 2088 s
PMID12699744 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12699744/
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