Peptide Database

Peptide NameAlpha-latrotoxin associated low molecular weight protein 2 (Alpha-latrotoxin-associated LMWP2) (Latrodectin-2)

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuromodulation

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Standard StatusStandard

Sequence Length78 amino acids

Chemical FormulaC386H605N103O144S7

DescriptionStandard

        ADNEDELTIEDFLSYECNESMDIEELKEKDKVCSRCANLHKTQSVIERCRLNCFTSEYFKNCEDNLQAKEEEPEEETL
    

Molecular Weight9216.99 Da

Isoelectric Point (pI)4.24

Net Charge (pH 7.0)-14.13

Net Charge (pH 7.4) -14.50

Charge Density (pH 7.0) -0.1812

GRAVY Index-1.03

Hydrophobic Moment 0.54

Boman Index-0.26

Instability Index75.74

Aliphatic Index 61.28

Aromaticity 0.0641

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3355.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 4090.88

LogP -44.63

H-bond Donors 142.0

H-bond Acceptors 138.0

Rotatable Bonds 323.0

Heavy Atoms 640.0

Ring Count 7.0

Amide Bonds 85.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0254088 VERIFIED: YES

Provenance & Taxonomy

OrganismSteatoda grossa [Animal]

FamilyAlpha-latrotoxin associated low molecular weight protein 2 (Alpha-latrotoxin-associated LMWP2) (Latrodectin-2)

Tax ID256750

Structure & Mods

Configdisulfide-constrained peptide [Cyclic]

Chiralitycanonical L-amino-acid peptide [L]

Disulfide17-53; 33-49; 36-62

Bio-Activity Profile

Function

Hormone Endocrine Neuropeptide Neuromodulator

Half-LifeMammalian: 4.4 hour; Yeast: >20 hour; E. coli: >10 hour