Peptide Database

Peptide Nameadrenocorticotrophic hormone

Function Ontology

Hormonal / Endocrine ▸ Hormone peptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide

Neurological / Signaling ▸ Neuropeptide activity ▸ Neuropeptide precursor

Standard StatusStandard

Sequence Length39 amino acids

Chemical FormulaC207H315N59O60S3

DescriptionStandard

        SYSMEHFRWGKPMGRKRRPIKVYPNSFEDESVENMGPEL
    

Molecular Weight4686.27 Da

Isoelectric Point (pI)8.13

Net Charge (pH 7.0)0.56

Net Charge (pH 7.4) 0.28

Charge Density (pH 7.0) 0.0143

GRAVY Index-1.21

Hydrophobic Moment 0.65

Boman Index-0.25

Instability Index50.33

Aliphatic Index 34.87

Aromaticity 0.1282

Extinction Coeff. Reduced 8480.00

Extinction Coeff. Oxidized 8480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1935.45

LogP -17.57

H-bond Donors 67.0

H-bond Acceptors 65.0

Rotatable Bonds 153.0

Heavy Atoms 329.0

Ring Count 11.0

Amide Bonds 40.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0050689 VERIFIED: YES

Provenance & Taxonomy

OrganismSqualus acanthias [Animal]

FamilyPOMC

Tax ID7797

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone precursor Neuropeptide precursor

RECORD: Rec_0110690 VERIFIED: NO

Provenance & Taxonomy

OrganismSqualus acanthias [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Hormone

RECORD: Rec_0330428 VERIFIED: YES

Provenance & Taxonomy

OrganismSqualus acanthias [Animal]

FamilyCorticotropin

Tax ID7797

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Other Mods13:Methionine amide

Bio-Activity Profile

Function

Hormone Endocrine

Half-LifeMammalian: 1.9 hour; Yeast: >20 hour; E. coli: >10 hour

RECORD: Rec_0375742 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Neuropeptide

Paper数据库级溯源文献：Wang Y, Wang M, Yin S, et al. NeuroPep: a comprehensive resource of neuropeptides. Database (Oxford). 2015:bav038. PMID 25931458; Bin Y, Zhang W, Tang W, et al. Prediction of Neuropeptides from Sequence Information Using Ensemble Classifier and Hybrid Features. J Proteome Res. 2020;19(9):3732-3740. PMID 32786686. PMID25931458;32786686 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25931458/