Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length409 amino acids

Chemical FormulaC2030H3167N539O578S24

DescriptionStandard

        HIFSSLALPTFISFLKKATKQQHKQDKNLTGMRHFAAGVIQDKLGEVTIPEVRGKIAGIHYTLSGMQIAKVDLPEPSVHFSPNVSGLDLSVSGLCVAVTGDWETHLGFIHDGGTFDMAVFDLSLRSVLTVNRDSGGRLSVFSVSCEADIESVDLRFYGGASWMFQWLVQYFTGHIKKLIQTNICPPVEDAIQCLEQHLQAMEGITASSFNNTSTDSNRWCSSSKYVNQRVLQGSSEASRPATPFWPAFSIPVPRRMCFVGCVRVHANSASFAYYDSGHLQAFINDSMVPPFCPVRLNTSSMGRYIPQLPKLFPNLLMELQVYARQIPLFSFEPDFVKLNLPSGVKAFAVLPNATLTPLFKLKVVRTLSASIHFLDSCLNGELLLSCMVTLPSCALVIMVNTTCRVENCT
    

Molecular Weight45140.68 Da

Isoelectric Point (pI)7.98

Net Charge (pH 7.0)2.71

Net Charge (pH 7.4) 1.64

Charge Density (pH 7.0) 0.0066

GRAVY Index0.14

Hydrophobic Moment 0.72

Boman Index0.14

Instability Index49.30

Aliphatic Index 91.25

Aromaticity 0.0954

Extinction Coeff. Reduced 39420.00

Extinction Coeff. Oxidized 40170.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0070107 VERIFIED: NO

Provenance & Taxonomy

OrganismNeogobius melanostomus [Animal]

FamilyBPI

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin

TargetGram-negative bacteria

MethodQualitative functional evidence