Peptide Database

Peptide NameSLAY-screened peptide P5741

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length21 amino acids

Chemical FormulaC103H175N25O27S3

DescriptionStandard

        MTCLICLPFLLVSPSITRLGN
    

Molecular Weight2291.84 Da

Isoelectric Point (pI)7.83

Net Charge (pH 7.0)0.48

Net Charge (pH 7.4) 0.24

Charge Density (pH 7.0) 0.0229

GRAVY Index1.30

Hydrophobic Moment 0.49

Boman Index0.40

Instability Index70.89

Aliphatic Index 143.81

Aromaticity 0.0476

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 813.65

LogP -5.54

H-bond Donors 30.0

H-bond Acceptors 31.0

Rotatable Bonds 71.0

Heavy Atoms 158.0

Ring Count 3.0

Amide Bonds 21.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0303716 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/