Peptide Database

Peptide NamePulmonary surfactant-associated anionic peptide Fr.6

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Standard StatusStandard

Sequence Length7 amino acids

Chemical FormulaC25H35N7O18

DescriptionStandard

        GADDDDD
    

Molecular Weight721.58 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-5.23

Net Charge (pH 7.4) -5.44

Charge Density (pH 7.0) -0.7473

GRAVY Index-2.30

Hydrophobic Moment 0.26

Boman Index-0.49

Instability Index-15.69

Aliphatic Index 14.29

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 424.42

LogP -6.67

H-bond Donors 13.0

H-bond Acceptors 13.0

Rotatable Bonds 23.0

Heavy Atoms 50.0

Ring Count 0.0

Amide Bonds 6.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0011247 VERIFIED: NO

Provenance & Taxonomy

OrganismOvis aries [Animal]

Tax ID9940

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

-

RECORD: Rec_0158915 VERIFIED: YES

Provenance & Taxonomy

OrganismOvis aries [Animal]

Tax ID9940

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

RECORD: Rec_0343804 VERIFIED: YES

Provenance & Taxonomy

OrganismOvis aries [Animal]

Tax ID9940

Structure & Mods

Configlinear peptide [Linear]

Chiralitymixed L/D amino-acid peptide [Mixed]

Other Modsallo-residue reported

Bio-Activity Profile

Function

Antimicrobial

Targetin the presence of 10 uM ZnCl2. A recent study tested additional bacteria and found this peptide was inactive

Activity>512 μg/mL

MethodMIC

RECORD: Rec_0344407 VERIFIED: YES

Provenance & Taxonomy

OrganismOvis aries [Animal]

Tax ID9940

Structure & Mods

Configtopology not specified [Not included yet]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

TargetGram-negative bacterium: Pasteurella haemolytica (MBC50=0.02 mM in Zn-saline, MBC50=10.10 mM in Test buffer; Peptide/surfactant mixture MBC50=0.04 mM in Zn-saline, MBC50=5.18 mM in Test buffer; Peptide/serum mixture MBC50=0.04 mM in Zn-saline, MBC50=5.59 mM in Test buffer; Peptide/surfactant/serum mixture MBC50=0.04 mM in Zn-saline, MBC50=4.75 mM in Test buffer)

RECORD: Rec_0363932 VERIFIED: YES

Provenance & Taxonomy

OrganismOvis sp. [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Anti-Gram-negative

TargetMannheimia haemolytica