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MYP_016635
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Basic Information
Citropin 1.1 [D4K][S11K][G14K][G15K]
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
16 amino acids
C89H162N22O17
Standard
Sequence
GLFKVIKKVAKVIKKL
Physicochemical Analysis
1812.38 Da
10.70
5.75
5.54
0.3596
0.62
0.89
0.09
-31.86
158.12
0.0625
0.00
0.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
655.94
-0.51
23.0
23.0
68.0
128.0
1.0
15.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0213983 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Aurein
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Streptococcus uberis
50 μg/mL
MIC
PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0215685 VERIFIED: YES
Provenance & Taxonomy
Amphibian skin [Animal]
Citropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Renal cancer group (NCI)
10 μM
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1. Eur J Biochem. 2003 Mar;270(6):1141-1153. doi: 10.1046/j.1432-1033.2003.03462.x. PMID: 12631273. PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0217035 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
PaperCancerPPD: a database of anticancer peptides and proteins PMID25270878 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/25270878/
RECORD: Rec_0223227 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Amphibian skin secretions
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Anticancer Cytotoxic
Brain tumor cell line
5
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1 PMID12631273;9266696 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
RECORD: Rec_0231850 VERIFIED: YES
Provenance & Taxonomy
Amphibian skin [Animal]
Citropin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
Amidation
Bio-Activity Profile
Antimicrobial Anticancer
Melanoma cancer group (NCI)
10 μM
IC50
PapernNOS inhibition, antimicrobial and anticancer activity of the amphibian skin peptide, citropin 1.1 and synthetic modifications. The solution structure of a modified citropin 1.1. Eur J Biochem. 2003 Mar;270(6):1141-1153. doi: 10.1046/j.1432-1033.2003.03462.x. PMID: 12631273. PMID12631273 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/12631273/
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