Peptide Database

Peptide NameSLAY-screened peptide P896

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC100H150N36O32

DescriptionStandard

        RSTFHIGDGNNNHRDKSHYL
    

Molecular Weight2368.48 Da

Isoelectric Point (pI)8.61

Net Charge (pH 7.0)1.02

Net Charge (pH 7.4) 0.66

Charge Density (pH 7.0) 0.0511

GRAVY Index-1.67

Hydrophobic Moment 0.33

Boman Index-0.37

Instability Index73.09

Aliphatic Index 39.00

Aromaticity 0.1000

Extinction Coeff. Reduced 1490.00

Extinction Coeff. Oxidized 1490.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1136.87

LogP -15.35

H-bond Donors 40.0

H-bond Acceptors 36.0

Rotatable Bonds 78.0

Heavy Atoms 168.0

Ring Count 5.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0249969 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/