Peptide Database

Peptide NameSHP1

Function Ontology

Anticancer

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length9 amino acids

Chemical FormulaC38H63N11O18

DescriptionStandard

        TESQTNSVP
    

Molecular Weight961.97 Da

Isoelectric Point (pI)4.05

Net Charge (pH 7.0)-1.60

Net Charge (pH 7.4) -1.79

Charge Density (pH 7.0) -0.1777

GRAVY Index-1.21

Hydrophobic Moment 0.18

Boman Index-0.18

Instability Index77.79

Aliphatic Index 32.22

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 491.73

LogP -8.81

H-bond Donors 16.0

H-bond Acceptors 17.0

Rotatable Bonds 29.0

Heavy Atoms 67.0

Ring Count 1.0

Amide Bonds 10.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0021864 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Confighydrocarbon-stapled side-chain cyclic peptide [Cyclic]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermFITC, 5(6)-carboxy fluorescence

C-TermNone

Other ModsStapled: Ⓧ(3) and Ⓧ (7) are cross-linked by hydrocarbon stapling

Bio-Activity Profile

Function

Anticancer Antimicrobial Antibacterial

PaperAdak A, Das G, Gupta V, Khan J, Mukherjee N, Mondal P, Roy R, Barman S, Gharai PK, Ghosh S. Evolution of Potential Antimitotic Stapled Peptides from Multiple Helical Peptide Stretches of the Tubulin Heterodimer Interface: Helix-Mimicking Stapled Peptide Tubulin Inhibitors. J Med Chem. 2022 Oct 27;65(20):13866-13883. PMID36240440 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/36240440/