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MYP_016595
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Basic Information
Warnerin
Antimicrobial
Antimicrobial ▸ Antibacterial
Standard
30 amino acids
C130H238N38O39S3
Standard
Sequence
ASVVKTTIKASKKLCKGATLTCGCNITGKK
Physicochemical Analysis
3053.71 Da
9.95
6.76
6.52
0.2253
0.03
0.61
-0.02
6.37
81.33
0.0000
0.00
125.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1274.06
-16.64
49.0
49.0
109.0
210.0
0.0
30.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0272571 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus warneri [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
Active against S
PaperPubMed PMID: 19361283 PMID19361283 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19361283/
RECORD: Rec_0325507 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus warneri [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
206-215 and the reports by Russians on warnerin can be traced to 2005. APD analysis reveals that the sequence of THE PEPTIDE shows 80.6% similarity to Epilancin 15X. Based on this similarity, a structural model has been proposed (Polyudova et al. 2017 Applied Biochem Microbiol 53:40-46). In this model, there are three thioether bonds S11-C15, T19-C22, and T21-C24. In addition, S2, TT6, T7, and T27 are dehydrated (XXW4) into Dha for S and Dhb for T. The N-terminal chemical modification of the peptide is yet to be elucidated. Active against S. epidermis (MIC <1 ug/ml), S. epidermis ATCC 700566 (MIC 8 ug/ml), S. epidermis ATCC 700567 (MIC 8 ug/ml), Staphylococcus sp. ATCC 700575 (MIC 32 ug/ml), S. aureus (VISA) CCUG 45315 (MIC 1.5 ug/ml), K. pneumoniae ATCC 700603 (MIC 96 ug/ml), E. faecium ATCC 51559 (MIC 64 ug/ml), and E. faecium (anti-VRE) ATCC 700221 (MIC 32 ug/ml). A patent has been issued. Provided and deposited by Daria Eroshenko,Tatyana Polyudova and Vladimir Korobov March 9, 2017
Bio-Activity Profile
Antimicrobial
ATCC 700221
32 μg/mL
MIC
PaperIdentification and characterization of a bioactive lantibiotic produced by Staphylococcus warneri.
RECORD: Rec_0332737 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus warneri [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
206-215 and the reports by Russians on warnerin can be traced to 2005. APD analysis reveals that the sequence of THE PEPTIDE shows 80.6% similarity to Epilancin 15X. Based on this similarity, a structural model has been proposed (Polyudova et al. 2017 Applied Biochem Microbiol 53:40-46). In this model, there are three thioether bonds S11-C15, T19-C22, and T21-C24. In addition, S2, TT6, T7, and T27 are dehydrated (XXW4) into Dha for S and Dhb for T. The N-terminal chemical modification of the peptide is yet to be elucidated. Active against S. epidermis (MIC <1 ug/ml), S. epidermis ATCC 700566 (MIC 8 ug/ml), S. epidermis ATCC 700567 (MIC 8 ug/ml), Staphylococcus sp. ATCC 700575 (MIC 32 ug/ml), S. aureus (VISA) CCUG 45315 (MIC 1.5 ug/ml), K. pneumoniae ATCC 700603 (MIC 96 ug/ml), E. faecium ATCC 51559 (MIC 64 ug/ml), and E. faecium (anti-VRE) ATCC 700221 (MIC 32 ug/ml). A patent has been issued. Provided and deposited by Daria Eroshenko,Tatyana Polyudova and Vladimir Korobov March 9, 2017
Bio-Activity Profile
Antimicrobial
CCUG 45315
1.5 μg/mL
MIC
PaperIdentification and characterization of a bioactive lantibiotic produced by Staphylococcus warneri.
RECORD: Rec_0354028 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus warneri [Bacterium]
Bacteriocin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
206-215 and the reports by Russians on warnerin can be traced to 2005. APD analysis reveals that the sequence of THE PEPTIDE shows 80.6% similarity to Epilancin 15X. Based on this similarity, a structural model has been proposed (Polyudova et al. 2017 Applied Biochem Microbiol 53:40-46). In this model, there are three thioether bonds S11-C15, T19-C22, and T21-C24. In addition, S2, TT6, T7, and T27 are dehydrated (XXW4) into Dha for S and Dhb for T. The N-terminal chemical modification of the peptide is yet to be elucidated. Active against S. epidermis (MIC <1 ug/ml), S. epidermis ATCC 700566 (MIC 8 ug/ml), S. epidermis ATCC 700567 (MIC 8 ug/ml), Staphylococcus sp. ATCC 700575 (MIC 32 ug/ml), S. aureus (VISA) CCUG 45315 (MIC 1.5 ug/ml), K. pneumoniae ATCC 700603 (MIC 96 ug/ml), E. faecium ATCC 51559 (MIC 64 ug/ml), and E. faecium (anti-VRE) ATCC 700221 (MIC 32 ug/ml). A patent has been issued. Provided and deposited by Daria Eroshenko,Tatyana Polyudova and Vladimir Korobov March 9, 2017
Bio-Activity Profile
Antimicrobial
Klebsiella pneumoniae ATCC 700603
96 μg/mL
MIC
PaperIdentification and characterization of a bioactive lantibiotic produced by Staphylococcus warneri.
RECORD: Rec_0392142 VERIFIED: YES
Provenance & Taxonomy
Staphylococcus warneri [Bacterium]
Bacteriocin
Structure & Mods
topology not specified [Not included yet]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial
epidermis ATCC 700567
8 μg/mL
MIC
PaperPubMed PMID: 19361283 PMID19361283 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/19361283/
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