Peptide Database

Peptide NameSLAY-screened peptide P5631

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length19 amino acids

Chemical FormulaC93H150N28O24S2

DescriptionStandard

        VHRATPCLSRPPGMLTQPF
    

Molecular Weight2108.49 Da

Isoelectric Point (pI)10.35

Net Charge (pH 7.0)1.81

Net Charge (pH 7.4) 1.54

Charge Density (pH 7.0) 0.0953

GRAVY Index-0.21

Hydrophobic Moment 0.65

Boman Index0.02

Instability Index62.36

Aliphatic Index 61.58

Aromaticity 0.0526

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 808.22

LogP -8.01

H-bond Donors 28.0

H-bond Acceptors 29.0

Rotatable Bonds 60.0

Heavy Atoms 147.0

Ring Count 6.0

Amide Bonds 19.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0200704 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/