Peptide Database

Peptide NameSLAY-screened peptide P5375

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Standard StatusStandard

Sequence Length20 amino acids

Chemical FormulaC110H154N30O26S3

DescriptionStandard

        NDFLCVVRAPFWAHCNLWNC
    

Molecular Weight2408.78 Da

Isoelectric Point (pI)6.72

Net Charge (pH 7.0)-0.18

Net Charge (pH 7.4) -0.48

Charge Density (pH 7.0) -0.0091

GRAVY Index0.38

Hydrophobic Moment 0.45

Boman Index0.22

Instability Index26.03

Aliphatic Index 78.00

Aromaticity 0.2000

Extinction Coeff. Reduced 11000.00

Extinction Coeff. Oxidized 11125.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 896.16

LogP -5.39

H-bond Donors 33.0

H-bond Acceptors 30.0

Rotatable Bonds 69.0

Heavy Atoms 169.0

Ring Count 8.0

Amide Bonds 22.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0043657 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Familyp53-derived

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitystereochemistry not specified [Other]

Bio-Activity Profile

Function

Antimicrobial Antibacterial

Targetrecombinant Escherichia coli surface-display screening

MethodSLAY screening

PaperAshley T Tucker, Sean P Leonard, Cory D DuBois, Gregory A Knauf, Ashley L Cunningham, Claus O Wilke, M Stephen Trent, Bryan W Davies. Discovery of Next-Generation Antimicrobials through Bacterial Self-Screening of Surface-Displayed Peptide Libraries. Cell. 2018 Jan 25;172(3):618-628.e13. doi: 10.1016/j.cell.2017.12.009. Epub 2018 Jan 4. PMID29307492 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/29307492/