MYP_016533
apicidin A
Anticancer
Venom / Toxin
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General toxin
▸
Toxin
not Standard
4 amino acids
-
contains X representing unresolved or non-standard residue
XXIW
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Amino Acid Composition
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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RECORD: Rec_0183805
VERIFIED: YES
Provenance & Taxonomy
not reported [other]
apicidin
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Fatty acylation (C10:0-NH2(2)-oxo(8))
Non-proteinogenic/modified monomers: D-Hpr
Bio-Activity Profile
Histone deacetylase inhibitor
Enzyme inhibitory
Antiprotozoal
Antiparasitic
Anticancer
Toxin
Eimeria tenella histone deacetylase
1.0 nM
IC50 (histone deacetylase inhibition assay)
RECORD: Rec_0432174
VERIFIED: YES
Provenance & Taxonomy
not reported [other]
apicidin
Structure & Mods
cyclic peptide [Cyclic]
mixed L/D amino-acid peptide [Mixed]
Fatty acylation (C10:0-NH2(2)-oxo(8))
Non-proteinogenic/modified monomers: D-Hpr
Bio-Activity Profile
Histone deacetylase inhibitor
Enzyme inhibitory
Antiprotozoal
Antiparasitic
Anticancer
Toxin
Eimeria tenella histone deacetylase-associated apicidin-binding site
4 nM
IC50 ([3H]apicidin A radioligand competition binding assay)