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MYP_016532
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Basic Information
Oncocin [P13Hyp,R15Hyp,I16Tle,R19Orn], Onc110
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antimicrobial ▸ Antibacterial
Toxicity / Safety ▸ Blood cell toxicity ▸ Hemolysis ▸ Hemolytic
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
not Standard
19 amino acids
-
contains X representing unresolved or non-standard residue
Sequence
VDKPPYLPRPRPXRXXYNX
Physicochemical Analysis
0.00 Da
0.00
0.00
0.00
0.00
0.00
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Residue Composition
Amino Acid Composition
Chemical Descriptors
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0049350 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 13,15,16,19
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa 60909001
0.5 μg/mL
MIC
PMID27285299;21387510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27285299/
RECORD: Rec_0053418 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 13,15,16,19
Bio-Activity Profile
Antimicrobial Antibacterial
Pseudomonas aeruginosa 70108001
1 μg/mL
MIC
PMID27285299;21387510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27285299/
RECORD: Rec_0062288 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 13,15,16,19
Bio-Activity Profile
Antimicrobial Antibacterial
Klebsiella pneumoniae ATCC 27799
0.25 μg/mL
MIC
PMID27285299;21387510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27285299/
RECORD: Rec_0074673 VERIFIED: YES
Provenance & Taxonomy
Synthetic construct [Synthetic]
Oncocin
32630
Structure & Mods
synthetic linear peptide [Linear]
mixed L/D or modified amino-acid peptide [Mixed]
None
Amidation
x=trans-4-hydroxyproline; X(16)=tert-Leu; X(19)=Orn
Bio-Activity Profile
Antimicrobial Anticancer
HeLa (20-25% Cytotoxicity=600 μg/ml)
PMID26334348 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/26334348/
RECORD: Rec_0089695 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
synthetic linear peptide [Linear]
noncanonical stereochemical modification [Modified]
unspecified non-canonical residue at 13,15,16,19
Bio-Activity Profile
Antimicrobial Antibacterial
Escherichia coli 70329001
0.5 μg/mL
MIC
PMID27285299;21387510 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/27285299/
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