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MYP_016510
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Basic Information
Phlebotomus duboscqi defensin (PduDef; defensins; Insects, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Standard
40 amino acids
C170H267N57O50S6
Standard
Sequence
ATCDLLSAFGVGHAACAAHCIGHGYRGGYCNSKAVCTCRR
Physicochemical Analysis
4101.68 Da
8.68
3.00
2.56
0.0749
0.22
0.48
0.10
33.67
61.25
0.0750
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1697.75
-22.69
68.0
62.0
129.0
283.0
6.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0198266 VERIFIED: YES
Provenance & Taxonomy
Phlebotomus duboscqi [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-30, 16-36, 20-36
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Antiparasitic
Trichophyton mentagrophytes
25-50 μM
MIC
PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
RECORD: Rec_0208706 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 25.0%, E 20.0%, T 30.0%, C 25.0% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antibacterial Antiparasitic Antimicrobial Antifungal Anti-Gram-positive Antileishmanial
PaperAPD2: the updated antimicrobial peptide database and its application in peptide design PMID18957441 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/18957441/
RECORD: Rec_0209933 VERIFIED: YES
Provenance & Taxonomy
Phlebotomus duboscqi [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
Aspergillus fumigatus
12.5-25 μM
MIC
PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
RECORD: Rec_0266811 VERIFIED: YES
Provenance & Taxonomy
Phlebotomus duboscqi [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-30, 16-36, 20-36
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Antiparasitic
Fusarium culmorum
1.56-3.12 μM
MIC
PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
RECORD: Rec_0284099 VERIFIED: YES
Provenance & Taxonomy
Phlebotomus duboscqi [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-30, 16-36, 20-36
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Antiparasitic
Aspergillus fumigatus
12.5-25 μM
MIC
PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
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