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MYP_016510
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Basic Information
Phlebotomus duboscqi defensin (PduDef; defensins; Insects, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Standard
40 amino acids
C170H267N57O50S6
Standard
Sequence
ATCDLLSAFGVGHAACAAHCIGHGYRGGYCNSKAVCTCRR
Physicochemical Analysis
4101.68 Da
8.68
3.00
2.56
0.0749
0.22
0.48
0.10
33.67
61.25
0.0750
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1697.75
-22.69
68.0
62.0
129.0
283.0
6.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0103986 VERIFIED: YES
Provenance & Taxonomy
Phlebotomus duboscqi [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
F. culmorum
1.56-3.12 μM
MIC
PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
RECORD: Rec_0126683 VERIFIED: YES
Provenance & Taxonomy
Phlebotomus duboscqi [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
S. cerevisiae
25-50 μM
MIC
PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
RECORD: Rec_0132230 VERIFIED: YES
Provenance & Taxonomy
Phlebotomus duboscqi [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
F. oxysporum
3.12-6.25 μM
MIC
PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
RECORD: Rec_0158476 VERIFIED: NO
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Anticancer
PaperAntiCP 2.0: an updated model for predicting anticancer peptides (benchmark provenance; exact sequence-level experiment paper unresolved here) | https://pubmed.ncbi.nlm.nih.gov/32770192/
RECORD: Rec_0170859 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antimicrobial Antiparasitic Antileishmanial
Leishmania major MHOM/YE/84
68-85 μM
IC50; Alamar Blue assay
PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
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