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MYP_016510
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Basic Information
Phlebotomus duboscqi defensin (PduDef; defensins; Insects, animals)
Anticancer
Antimicrobial
Antimicrobial ▸ Antibacterial
Antimicrobial ▸ Antibacterial ▸ Anti-Gram-positive
Antimicrobial ▸ Antifungal
Antiparasitic ▸ Anti-Leishmania ▸ Antileishmanial
Antiparasitic ▸ General antiparasitic ▸ Antiparasitic
Standard
40 amino acids
C170H267N57O50S6
Standard
Sequence
ATCDLLSAFGVGHAACAAHCIGHGYRGGYCNSKAVCTCRR
Physicochemical Analysis
4101.68 Da
8.68
3.00
2.56
0.0749
0.22
0.48
0.10
33.67
61.25
0.0750
2980.00
3355.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1697.75
-22.69
68.0
62.0
129.0
283.0
6.0
40.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0022069 VERIFIED: YES
Provenance & Taxonomy
Phlebotomus duboscqi [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-30, 16-36, 20-36
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Antiparasitic
Candida albicans
6.25-12.5 μM
MIC
PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
RECORD: Rec_0044822 VERIFIED: YES
Provenance & Taxonomy
Phlebotomus duboscqi [Animal]
Defensin
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antimicrobial Antibacterial Antifungal Anti-Gram-positive
T. viride
3.12-6.25 μM
MIC
PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
RECORD: Rec_0050732 VERIFIED: YES
Provenance & Taxonomy
Phlebotomus duboscqi [Animal]
Defensin
Structure & Mods
Disulfide-stabilized peptide [Linear]
noncanonical stereochemical modification [Modified]
three disulfide bonds
Bio-Activity Profile
Antimicrobial Antiparasitic
PaperCharacterization of a defensin from the sand fly Phlebotomus duboscqi induced by challenge with bacteria or the protozoan parasite Leishmania major PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
RECORD: Rec_0074008 VERIFIED: YES
Provenance & Taxonomy
Phlebotomus duboscqi [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-30, 16-36, 20-36
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Antiparasitic
Parasite: Leishmania major promastigote forms
68-85 μM
IC50
PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
RECORD: Rec_0101197 VERIFIED: YES
Provenance & Taxonomy
Phlebotomus duboscqi [Animal]
Defensin
Structure & Mods
disulfide-constrained cyclic peptide [Cyclic]
canonical L-amino-acid peptide [L]
None
None
3-30, 16-36, 20-36
Bio-Activity Profile
Antimicrobial Antibacterial Anti-Gram-positive Antifungal Antiparasitic
Saccharomyces cerevisiae
25-50 μM
MIC
PMID15557638 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15557638/
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