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MYP_016503
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Basic Information
Unnamed
Antimicrobial
Antiviral
Antiviral ▸ Anti-HPV
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition
Antiviral ▸ Antiviral mechanism ▸ Viral entry inhibition ▸ Entry inhibitor
Standard
8 amino acids
C44H69N9O15
Standard
Sequence
YLQELLGE
Physicochemical Analysis
964.07 Da
4.24
-2.23
-2.44
-0.2787
-0.10
0.40
0.20
64.15
146.25
0.1250
1490.00
1490.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
404.94
-1.50
13.0
13.0
32.0
68.0
1.0
8.0
Structural Visualization
3D PDB MODEL
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2D CHEMICAL STRUCTURE
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Experimental Records
RECORD: Rec_0154962 VERIFIED: YES
Provenance & Taxonomy
not reported [other]
Structure & Mods
linear peptide; DSSP H 0.0%, E 0.0%, T 37.5%, C 62.5% [Linear]
canonical L-amino-acid peptide [L]
None
None
Bio-Activity Profile
Antiviral Antimicrobial
PaperAVPdb: a database of experimentally validated antiviral peptides targeting medically important viruses PMID24285301 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/24285301/
RECORD: Rec_0161522 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
Human papillomavirus(HPV):inhibition of E6-E6ap interaction
74.3±1.9 μM
IC50
PaperPubMed PMID: 15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/
RECORD: Rec_0180479 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
Protein-derived synthetic peptide
32630
Structure & Mods
synthetic linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antiviral Anti-HPV Entry inhibition
Human papillomavirus(HPV)
74.3±1.9 μM
IC50
Mammalian: 2.8 h; Yeast: 10 min; E. coli: 2 min
PaperDesign and characterization of helical peptides that inhibit the E6 protein of papillomavirus. | Liu Y, Liu Z, Androphy E, Chen J, Baleja JD. | Biochemistry. 2004 Jun 15;43(23):7421-31. | DOI:10.1021/bi049552a | PMID:15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/
RECORD: Rec_0212424 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Acetylation
Amidation
Bio-Activity Profile
Antimicrobial Antiviral
PaperPubMed PMID: 15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/
RECORD: Rec_0396130 VERIFIED: YES
Provenance & Taxonomy
Homo sapiens [Animal]
Host-derived peptide
9606;0
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral Entry inhibitor
Human papillomavirus (E6 protein)
74.3 μM
CD spectroscopy
PaperDesign and characterization of helical peptides that inhibit the E6 protein of papillomavirus. | Liu Y, Liu Z, Androphy E, Chen J, Baleja JD. | Biochemistry. 2004 | PMID:15182185 PMID15182185 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/15182185/