Peptide Database

Peptide NamePotassium channel toxin alpha-KTx 6, Hetlaxin

Function Ontology

Membrane / Ion-channel modulation ▸ Ion channel modulation

Venom / Toxin ▸ General toxin ▸ Toxin

Standard StatusStandard

Sequence Length34 amino acids

Chemical FormulaC148H246N44O47S9

DescriptionStandard

        ISCTGSKQCYDPCKKKTGCPNAKCMNKSCKCYGC
    

Molecular Weight3682.39 Da

Isoelectric Point (pI)9.03

Net Charge (pH 7.0)5.67

Net Charge (pH 7.4) 5.34

Charge Density (pH 7.0) 0.1669

GRAVY Index-0.70

Hydrophobic Moment 0.49

Boman Index-0.21

Instability Index62.68

Aliphatic Index 14.41

Aromaticity 0.0588

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 3480.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1496.36

LogP -21.41

H-bond Donors 59.0

H-bond Acceptors 62.0

Rotatable Bonds 124.0

Heavy Atoms 248.0

Ring Count 4.0

Amide Bonds 36.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0057600 VERIFIED: YES

Provenance & Taxonomy

OrganismHeterometrus laoticus [Animal]

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

C-TermAmidation

Bio-Activity Profile

Function

Toxin Ion Channel Blocker Potassium Channel Blocker

TargetKv1.1/KCNA1

Activity6.7 μM

MethodIC50

RECORD: Rec_0303747 VERIFIED: YES