Peptide Database

Peptide NameBactericidal permeability-increasing protein (BPI)

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial ▸ Anti-Gram-negative

Antimicrobial ▸ Antibiotic activity

Toxicity / Safety ▸ Negative safety assay result ▸ Non-hemolytic

Venom / Toxin ▸ General toxin ▸ Cytotoxin

Standard StatusStandard

Sequence Length240 amino acids

Chemical FormulaC1214H1878N296O328S9

DescriptionStandard

        MLLCKPTHGPSSSPLVTTKIDQVAGINYSLVAPLTATADSLDGQLKGEFYNVAQPSPAPFGPPALAFPPDHERMVYLGFSDYFFNTAGLVYQQAGVLHLTVMDDMIPKGSKFRLTTTFLGALIPQVAKMFPNMTVQLNIWASSPPHLTMLPTGLVFTPALETQAFAVLPNSSLAPLFVLHLVEVLQAIMNYVLPTIAIPKINERLQKGFPLPLPANVQLFNLVLQSHQNFLLFGADVHYS
    

Molecular Weight26156.27 Da

Isoelectric Point (pI)6.35

Net Charge (pH 7.0)-1.89

Net Charge (pH 7.4) -2.51

Charge Density (pH 7.0) -0.0079

GRAVY Index0.33

Hydrophobic Moment 0.65

Boman Index0.26

Instability Index41.89

Aliphatic Index 103.21

Aromaticity 0.1000

Extinction Coeff. Reduced 15930.00

Extinction Coeff. Oxidized 15930.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0168066 VERIFIED: NO

Provenance & Taxonomy

OrganismUrsus americanus [Animal]

FamilyBPI

Tax ID9643

Structure & Mods

Configlinear polypeptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antibiotic Antimicrobial Anti-Gram-negative Cytotoxin Non-hemolytic

TargetGram-negative bacteria

MethodQualitative functional evidence