Peptide Database

Peptide NameMUC7 15-mer

Function Ontology

Antimicrobial

Antimicrobial ▸ Antibacterial

Antimicrobial ▸ Antifungal

Standard StatusStandard

Sequence Length15 amino acids

Chemical FormulaC85H135N41O23

DescriptionStandard

        RERDHELRHRRHHHQ
    

Molecular Weight2099.24 Da

Isoelectric Point (pI)11.40

Net Charge (pH 7.0)2.20

Net Charge (pH 7.4) 1.74

Charge Density (pH 7.0) 0.1468

GRAVY Index-3.25

Hydrophobic Moment 0.25

Boman Index-1.12

Instability Index86.04

Aliphatic Index 26.00

Aromaticity 0.0000

Extinction Coeff. Reduced 0.00

Extinction Coeff. Oxidized 0.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1078.61

LogP -12.15

H-bond Donors 40.0

H-bond Acceptors 30.0

Rotatable Bonds 72.0

Heavy Atoms 149.0

Ring Count 5.0

Amide Bonds 15.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0046891 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyHistatin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other Modsidentified via sequence alignment with his-rich peptides. MUC7 itself is not antifungal. The protein could be cleaved in saliva. Exposure of MUC7 with whole saliva results in rapid degradation of protein. However, the protein is slowly cleaved by C. albicans, leading to detectable fragments. Sequence analysis: APD analysis reveals that this sequence is similar (37.5%) to Hcl-hst5 R=H: 33%, E: 13%. GRAVY: -3.25; mol wt: 2099.272; mol formula: C85H135N41O23; mol ex coeff: 0

Bio-Activity Profile

Function

Antifungal

TargetC-terminal amidation increased peptide activity

Activity16.52 μM

MethodED50

RECORD: Rec_0163384 VERIFIED: YES

Provenance & Taxonomy

Organismnot reported [other]

FamilyHistatin

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermAcetylation

C-TermAmidation

Other Modsidentified via sequence alignment with his-rich peptides. MUC7 itself is not antifungal. The protein could be cleaved in saliva. Exposure of MUC7 with whole saliva results in rapid degradation of protein. However, the protein is slowly cleaved by C. albicans, leading to detectable fragments. Sequence analysis: APD analysis reveals that this sequence is similar (37.5%) to Hcl-hst5 R=H: 33%, E: 13%. GRAVY: -3.25; mol wt: 2099.272; mol formula: C85H135N41O23; mol ex coeff: 0

Bio-Activity Profile

Function

Antifungal

TargetCandida albicans

Activity39.95 μM

MethodED50

RECORD: Rec_0182618 VERIFIED: NO

Provenance & Taxonomy

OrganismHomo sapiens [Animal]

Tax ID9606

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

Bio-Activity Profile

Function

Antimicrobial Antibacterial Antifungal