‹ ›
MYP_016061
← PREVIOUS NEXT → BACK
Basic Information
EK1C4
Anticancer
Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic
Antimicrobial
Antiviral
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV
Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2
Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor
Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross
Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic
Venom / Toxin ▸ General toxin ▸ Cytotoxic
Standard
41 amino acids
C208H336N48O71S
Standard
Sequence
SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSG
Physicochemical Analysis
4677.24 Da
4.36
-5.52
-5.76
-0.1347
-0.45
0.75
-0.02
21.17
104.63
0.0732
2980.00
2980.00
The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.
Residue Composition
Amino Acid Composition
Chemical Descriptors
1958.21
-15.67
66.0
67.0
168.0
328.0
3.0
42.0
Structural Visualization
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber in the current view mode. Use the buttons to zoom.
2D CHEMICAL STRUCTURE
Drag to move
Drag to move. Use the buttons to zoom.
Experimental Records
RECORD: Rec_0375637 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
PEG4-Chol
PEG4-Chol
Bio-Activity Profile
Antiviral Anti-HCoV-NL63 Fusion inhibition
HCoV-NL63 | Huh-7 cells; LLC-MK2 cells
0.0766 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. | Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L. | Cell Res. 2020 Apr;30(4):343-355. | DOI:10.1038/s41422-020-0305-x | PMID:32231345 PMID32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32231345/
RECORD: Rec_0376061 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
PEG4-Chol
PEG4-Chol
Bio-Activity Profile
Antiviral Anti-SARS-CoV-2 Fusion inhibition
SARS-CoV-2 | 293T/ACE2 cells; VERO-E6 cells
2.468 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. | Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L. | Cell Res. 2020 Apr;30(4):343-355. | DOI:10.1038/s41422-020-0305-x | PMID:32231345 PMID32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32231345/
RECORD: Rec_0382515 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
None
PEG4-25-HC
Bio-Activity Profile
Antimicrobial Anti-SARS-CoV-2 Cytotoxic Anticancer
toxicity against Caco-2 cells at concentrations of up to 20 μM
20 μM
Cytotoxicity
PMID34769299 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34769299/
RECORD: Rec_0385321 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
HR2 fusion-inhibitory peptide
32630
Structure & Mods
linear peptide [Linear]
noncanonical stereochemical modification [Modified]
None
PEG4-Chol
PEG4-Chol
Bio-Activity Profile
Antiviral Anti-HCoV-OC43 Fusion inhibition
HCoV-OC43 | 293T/ACE2 cells; RD cells
0.0377 μM
IC50
Mammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h
PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. | Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L. | Cell Res. 2020 Apr;30(4):343-355. | DOI:10.1038/s41422-020-0305-x | PMID:32231345 PMID32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32231345/
RECORD: Rec_0388148 VERIFIED: YES
Provenance & Taxonomy
synthetic construct [Synthetic]
32630
Structure & Mods
linear peptide [Linear]
canonical L-amino-acid peptide [L]
Bio-Activity Profile
Antiviral
SARS-like CoV-Rs3367
PMID32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32231345/
FIRST PREV 1 ... 34 35 36 37 38 39 NEXT LAST
Showing 5 records on this page · Page 36 of 39