Peptide Database

Peptide NameEK1C4

Function Ontology

Anticancer

Anticancer ▸ Cytotoxic anticancer activity ▸ Cytotoxic

Antimicrobial

Antiviral

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV

Antiviral ▸ Anti-Coronavirus ▸ Anti-SARS-CoV-2

Antiviral ▸ Antiviral mechanism ▸ Viral fusion inhibition

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor

Membrane / Ion-channel modulation ▸ Sodium channel modulation ▸ Sodium channel inhibitor cross

Toxicity / Safety ▸ Cytotoxicity ▸ Cytotoxic

Venom / Toxin ▸ General toxin ▸ Cytotoxic

Standard StatusStandard

Sequence Length41 amino acids

Chemical FormulaC208H336N48O71S

DescriptionStandard

        SLDQINVTFLDLEYEMKKLEEAIKKLEESYIDLKELGSGSG
    

Molecular Weight4677.24 Da

Isoelectric Point (pI)4.36

Net Charge (pH 7.0)-5.52

Net Charge (pH 7.4) -5.76

Charge Density (pH 7.0) -0.1347

GRAVY Index-0.45

Hydrophobic Moment 0.75

Boman Index-0.02

Instability Index21.17

Aliphatic Index 104.63

Aromaticity 0.0732

Extinction Coeff. Reduced 2980.00

Extinction Coeff. Oxidized 2980.00

The radar chart summarizes major physicochemical dimensions for quick comparison, while exact numerical values remain listed on the left.

Amino Acid Composition

TPSA 1958.21

LogP -15.67

H-bond Donors 66.0

H-bond Acceptors 67.0

Rotatable Bonds 168.0

Heavy Atoms 328.0

Ring Count 3.0

Amide Bonds 42.0

3D PDB MODEL

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2D CHEMICAL STRUCTURE

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RECORD: Rec_0356754 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermPEG12-25-HC

Other ModsPEG12-25-HC

Bio-Activity Profile

Function

Antiviral Anti-SARS-CoV-2 Fusion inhibition

TargetSARS-CoV-2 | Caco2 cells

Activity5.2 μM

MethodIC50

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

Paper25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human Coronaviruses. | Lan Q, Wang C, Zhou J, Wang L, Jiao F, Zhang Y, Cai Y, Lu L, Xia S, Jiang S. | Int J Mol Sci. 2021 Nov 1;22(21):11869. | DOI:10.3390/ijms222111869 | PMID:34769299 PMID34769299 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/34769299/

RECORD: Rec_0360251 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermPEG4-Chol

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

TargetSARS-CoV-2 Delta:inhibition of cell-cell fusion

Activity0.00404 μM

MethodIC50

PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. PMID: 32231345 PMID35087243;32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/

RECORD: Rec_0361968 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermPEG4-Chol

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

TargetHCoV-NL63:inhibition of cell-cell fusion in Huh-7 cells

Activity0.0214 μM

MethodIC50

PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. PMID: 32231345 PMID35087243;32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/

RECORD: Rec_0368514 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitycanonical L-amino-acid peptide [L]

N-TermNone

C-TermPEG4-Chol

Bio-Activity Profile

Function

Antimicrobial Anti-SARS-CoV-2

Targetinhibit the replication of MERS-CoV in VERO-E6 cells

Activity0.0042 μM

MethodIC50

PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Res. 2020 Apr;30(4):343-355. doi: 10.1038/s41422-020-0305-x. PMID: 32231345 PMID35087243;32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/35087243/

RECORD: Rec_0372823 VERIFIED: YES

Provenance & Taxonomy

Organismsynthetic construct [Synthetic]

FamilyHR2 fusion-inhibitory peptide

Tax ID32630

Structure & Mods

Configlinear peptide [Linear]

Chiralitynoncanonical stereochemical modification [Modified]

N-TermNone

C-TermPEG4-Chol

Other ModsPEG4-Chol

Bio-Activity Profile

Function

Antiviral Anti-MERS-CoV Fusion inhibition

TargetMERS-CoV | Huh-7 cells; VERO-E6 cells

Activity0.0042 μM

MethodIC50

Half-LifeMammalian: 1.9 h; Yeast: >20 h; E. coli: >10 h

PaperInhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. | Xia S, Liu M, Wang C, Xu W, Lan Q, Feng S, Qi F, Bao L, Du L, Liu S, Qin C, Sun F, Shi Z, Zhu Y, Jiang S, Lu L. | Cell Res. 2020 Apr;30(4):343-355. | DOI:10.1038/s41422-020-0305-x | PMID:32231345 PMID32231345 Evidence URLhttps://pubmed.ncbi.nlm.nih.gov/32231345/

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